Work

An Activity‐Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363

Year: 2011

Type: article

Abstract: Profiling enzyme activities: A selective, activity-based imaging probe is described for the integral membrane hydrolase KIAA1363 and used to determine the subcellular localization and half-life of this enzyme in human cancer cells (see picture).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.201107236

Authors: Jae Won Chang, Raymond E. Moellering, Benjamin F. Cravatt

Institution: Scripps Research Institute

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Howard Hughes Medical Institute, National Cancer Institute

Awards: G1149233714, G2948931604, G4321753651