Work

Expression and function of neural cell adhesion molecule during limb regeneration.

Year: 1986

Type: article

Abstract: The neural cell adhesion molecule (NCAM) has been detected in regenerating limb bud of adult newts in addition to brain and peripheral nerves. In the regenerating tissue, NCAM was found primarily on mesenchymal cells and also in wound epidermis. Infusion of Fab fragments of antibodies to NCAM into limb buds at the early blastema stage delayed the regenerative process. Previous studies have indicated that NCAM serves as a homophilic ligand for adhesion among cells that express this molecule and, in doing so, can influence the interaction of nerves with their environment. The expression of NCAM in regenerating limb and the effects of antibody infusion are therefore consistent with the observation that limb regeneration requires interactions among axons and mesenchymal cells.

Source: Proceedings of the National Academy of Sciences

DOI: 10.1073/pnas.83.21.8395

Authors: C E Maier, M Watanabe, M Singer, I G McQuarrie, J Sunshine, U Rutishauser

Institution: Case Western Reserve University

Language: English

Topic: Planarian Biology and Electrostimulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: G2694927961