Work

Polyarginine Induces an Antitumor Immune Response through Binding to Toll‐Like Receptor 4

Year: 2013

Type: article

Abstract: A novel function of polyarginine as an activator of the immune system is reported. Single-molecule fluorescence imaging and single-molecule force measurements demonstrate that polyarginine binds specifically to the toll-like receptor 4 (TLR4), inducing receptor dimerization and activation. Moreover, polyarginine induced immune activation inhibits tumor growth. These results suggest the potential use of polyarginine for cancer immunotherapy.

Source: Small

DOI: 10.1002/smll.201302887

Authors: Yong Yang, Joy Wolfram, Xiaohong Fang, Haifa Shen, Mauro Ferrari

Institutions: Houston Methodist Research Institute, Chinese Academy of Sciences, Institute of Chemistry

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute