Year: 2011
Type: article
Abstract: Background Protoporphyrin IX (PPIX) was shown to strongly activate in vitro the soluble guanylate cyclase enzyme (sGC), which makes it an interesting drug candidate for treatment of hypertension [1,2]. In order to overcome the problem of PPIX poor bioavailability (especially in the case of oral administration), we decided to exploit the specific uptake pathway of vitamin B12, which was frequently used for delivering biologically active substances from the digestive system into the body cells. To this end, we embarked on the synthesis of a series of hybrid molecules, containing PPIX and vitamin B12 moieties, linked via chains of different length and chemical character [3].
Source: BMC Pharmacology
Authors: Dorota Gryko, Emil Martin
Institutions: Institute of Organic Chemistry, Polish Academy of Sciences
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W2172060733