Work

NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation

Year: 2015

Type: article

Abstract: The tRNA methytransferase NSun2 promotes cell proliferation, but the molecular mechanism has not been elucidated. Here, we report that NSun2 regulates cyclin-dependent kinase 1 (CDK1) expression in a cell cycle-dependent manner. Knockdown of NSun2 decreased the CDK1 protein level, while overexpression of NSun2 elevated it without altering CDK1 mRNA levels. Further studies revealed that NSun2 methylated CDK1 mRNA in vitro and in cells and that methylation by NSun2 enhanced CDK1 translation. Importantly, NSun2-mediated regulation of CDK1 expression had an impact on the cell division cycle. These results provide new insight into the regulation of CDK1 during the cell division cycle.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.00742-15

Authors: Junyue Xing, Jie Yi, Xiaoyu Cai, Hao Tang, Zhenyun Liu, Xiaotian Zhang, Jennifer L. Martindale, Xiaoling Yang, Bin Jiang, Myriam Gorospe, Wengong Wang

Institutions: Peking University, Peking Union Medical College Hospital, National Institutes of Health, National Institute on Aging

Language: English

Topic: RNA modifications and cancer

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2172336833

FWCI: 2.025

Cites: 43

Cited by: 114

Related to: 10