Mapping nonlinear receptive field structure in primate retina at single cone resolution
Year: 2015
Type: article
Abstract: The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals flowing from the input to the output of the primate retina, using a combination of large-scale multi-electrode recordings from an identified ganglion cell type, visual stimulation targeted at individual cone photoreceptors, and a hierarchical computational model. The results reveal nonlinear subunits in the circuity of OFF midget ganglion cells, which subserve high-resolution vision. The model explains light responses to a variety of stimuli more accurately than a linear model, including stimuli targeted to cones within and across subunits. The recovered model components are consistent with known anatomical organization of midget bipolar interneurons. These results reveal the spatial structure of linear and nonlinear encoding, at the resolution of single cells and at the scale of complete circuits.
Source: eLife
DOI: 10.7554/elife.05241
Institutions: Howard Hughes Medical Institute, Janelia Research Campus, Salk Institute for Biological Studies, Duke University, Duke Medical Center, Carl von Ossietzky Universität Oldenburg, University of Strathclyde, University of California, Santa Cruz, Columbia University, Courant Institute of Mathematical Sciences, Stanford Medicine, Stanford University
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W2172808591