Work

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Year: 2002

Type: article

Source: Bioorganic & Medicinal Chemistry Letters

DOI: 10.1016/s0960-894x(02)00827-2

Authors: Mark E. Fraley, Robert S. Rubino, William F. Hoffman, Scott R. Hambaugh, Kenneth L. Arrington, Randall W. Hungate, Mark T. Bilodeau, Andrew J. Tebben, Ruth Z. Rutledge, Richard L. Kendall, Rosemary C. McFall, William R. Huckle, Kathleen E. Coll, Kenneth A. Thomas

Institution: Merck & Co., Inc., Rahway, NJ, USA (United States)

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W2172905429

FWCI: 2.944

Cites: 24

Cited by: 88

Related to: 10