Work

A central role for TOR signalling in a yeast model for juvenile CLN3 disease

Year: 2015

Type: article

Abstract: highlighted a conserved key signalling hub in which multiple components functionally relate to this conserved disease gene. This signalling hub includes two major mitogen-activated protein kinase (MAPK) cascades, and centers on the Tor kinase complexes TORC1 and TORC2. We confirmed that yeast cells modelling CLN3 disease exhibit features consistent with dysfunction in the TORC pathways, and showed that modulating TORC function leads to a comprehensive rescue of defects in this yeast disease model. The same pathways may be novel targets in the development of therapies for the NCLs and related diseases.

Source: Microbial Cell

DOI: 10.15698/mic2015.12.241

Authors: Michael Bond, Rachel Brown, Charalampos Rallis, Jurg Bahler, Sara Mole

Institutions: MRC Laboratory for Molecular Cell Biology, University College London

Language: English

Topic: Lysosomal Storage Disorders Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $634