MOLECULAR EXPRESSION OF ESTROGEN RECEPTOR ALPHA (ERα) AND INTERLEUKIN 6 (IL-6) ON ACCELERATION OF HEALING PROCESS OF LONG BONE SHAFT FRACTURE BY IMMEDIATE REPETITIVE AXIAL COMPRESSION TENSION STABILIZATION (IREACT)
Year: 2008
Type: article
Abstract: Long bone fracture healing depends on multifactorial aspects, which are basically divided into general and local.
Healing of long bone fracture naturally needs 3 to 6 and sometimes up to 9 months period, which is considered a high
morbidity not only for the patient, but also for his/her family and the society in accordance of psychosocioeconomic
field. The aim of this study was to know the mechanism process of immediate and repetitive loading (IREACTS) to
accelerate healing process of long bone fracture. Estrogen receptor alpha (ER α) and interleukin 6 (IL6) were
determined by immunohistochemistry technique and ELISA. Research samples were bone tissue and serum prepared
from immediate and repetitive loading (IREACTS) compared to fracture without loading. The result showed that
healing process occurred more rapidly on immediate and repetitive loading (IREACTS) compared to fracture without
loading based on the expression of ER α and IL6 of bone tissues and serum. In conclusion, IREACTS induces the
mechanism to achieve bone healing by the process of secondary bone healing and can be used as a method for lowering
morbidity in patients with long bone fracture.
Source: Folia Medica Indonesiana
Author: Achmad Sjarwani
Language: English
Subfield: Orthopedics and Sports Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $98
OpenAlex ID: W2173227143