Year: 2015
Type: article
Abstract: Previous chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a low-cost, disposable device. Here, we demonstrate the feasibility of a new heater configuration suitable for isothermal amplification in which one reactant of an exothermic reaction is a liquid-gas phase-change material, thereby eliminating the need for a separate phase-change compartment. This design offers potentially enhanced performance and energy density compared to other chemical and electric heaters.
Source: PLoS ONE
Authors: Kamal G. Shah, Dylan Guelig, Steven Diesburg, Joshua Buser, Robert Burton, Paul LaBarre, Rebecca Richards-Kortum, Bernhard Weigl
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,382
OpenAlex ID: W2173584748