Work

Regulation Of Adenylyl Cyclase-Coupled Beta-Adrenergic Receptors

Year: 1988

Type: article

Abstract: HETEROLOGOUS DESENSITIZATION.. .••••• ...•• 409 Receptor Alterations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . .... . . . . . . . . . . . . ....... . ... . . . . . . . .... . . . . . . . . . . . 409 Alterations in Guanine Nucleotide Regulatory Proteins.. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ......... 410 Adenylyl Cyclase Alterations . . . . . . . . . . . . .. .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 412 HOMOLOGOUS DESENSITIZATION . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . .. . .. .. . . . . . . . . . . . . . . . ... . . . . . . . . ........ . . . . . ...... 413 Functional Uncoupling/Sequestration. . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...... . . . . . . . . . . . 413 Down-Regulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 414 Role of Receptor Phosphorylation i n Homologous Desensitization . . . . . . . . . . . . . . . , . . . . . . . . . . . . . 415 Involvement of a Receptor-Specific Kinase .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 415 Identification of the Phosphorylation Sites and Their Contribution to the Desensitization Process. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 418 Mechanism of Homologous Desensitization . . . . . . . . . ...... . . . . . . .. .. ... . . . . . . . . . . . .. . .... .... . . . . . . . . . ... 419

Source: Annual Review of Cell Biology

DOI: 10.1146/annurev.cb.04.110188.002201

Authors: Jeffrey L. Benovic, Michel Bouvier, Marc G. Caron, Robert J. Lefkowitz

Institutions: Howard Hughes Medical Institute, Duke Medical Center

Language: English

Topic: Receptor Mechanisms and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute