Are There Any Epigenetic Similarities Between Treatment Unresponsive Sarcoidosis, COPD and Severe Asthma?
Year: 2015
Type: article
Abstract: Sarcoidosis is characterized by non-caseating granulomas and several immunological abnormalities in many tissues including the lungs (pulmonary) and others such as skin, bone, heart (extra pulmonary) 1 .The aetiology of the disease is unknown although probably relates to an inflammatory/immune response to an unknown infectious agent. 1 This leads to tissue damage, remodeling of airways, airway hyperactivity and a resultant loss of lung function.Corticosteroids remain the mainstay of first line treatment in sarcoidosis although they are not effective in all patients.2,3.Recent evidence suggests that epigenetic mechanisms are involved in the control of inflammation and immune cell function in cancer 1 and in the molecular pathways implicated in other pulmonary disorders such as chronic obstructive lung disease (COPD), severe asthma and interstitial lung disease (IPF).4 These diseases are all associated with epithelial and mesenchymal cell remodelling within the airways and alveoli associated with altered patterns
Source: PubMed
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2174950671