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Utilising inorganic nanocarriers for gene delivery

Year: 2015
Type: review
Abstract: The delivery of genetic materials into cells to elicit cellular responses has been extensively studied by biomaterials scientists globally. Many materials such as lipids, peptides, viruses, synthetically modified cationic polymers and certain inorganic nanomaterials could be used to complex the negatively charged plasmids and deliver the formed package into cells. The recent literature on the delivery of genetic materials utilising inorganic nanoparticles is carefully examined in this review. We have picked out the most relevant references and concisely summarised the findings with illustrated examples. We further propose alternative approaches and suggest future pathways towards the practical use of multifunctional nanocarriers.
DOI: 10.1039/c5bm00277j
Institutions: Agency for Science, Technology and Research, National University of Singapore, Singapore Eye Research Institute, Institute of Materials Research and Engineering, University College London, Nanyang Technological University, National Institute of Education
Language: English
Open Access status: green
OpenAlex ID: W2175230332
FWCI: 5.369
Cites: 124
Cited by: 364
Related to: 10