Body Mass Index and Non-Hodgkin's Lymphoma Survival in an Ethnically Diverse Population: The Multiethnic Cohort Study.
Year: 2014
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Obesity increases the risk of death from several malignancies including breast and colon cancer. However, for non-Hodgkin's lymphoma (NHL), the association between pre-diagnostic body mass index (BMI) and survival is unclear. We examined the association between pre-diagnostic BMI overall and NHL-specific survival in the Multiethnic Cohort (MEC) study of African Americans, Native Hawaiians, Japanese Americans, Latinos, and Caucasians. METHODS: MEC participants free of NHL at cohort entry and diagnosed with NHL during follow-up were included in the analyses (N=1348). Body mass index (BMI) was based on self-reported weight and height at cohort entry. Cox proportional hazards regression was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for pre-diagnostic BMI categories in relation to all-cause and NHL-specific mortality while adjusting for known confounders. RESULTS: The mean time from cohort entry to NHL diagnosis was 7.2±3.9 years (range: 0.0–15.0 years). The mean age at NHL diagnosis was 70.6 (range 45–89) years and the mean BMI at cohort entry was 26.5±4.7 kg/m2. After a mean follow-up of 4.3±3.5 years, 679 deaths including 457 NHL-specific deaths occurred. In multivariable models, obese patients (BMI ≥ 30.0) had higher all-cause (HR = 1.55, 95%CI = 1.21 −2.00) and NHL-specific (HR = 1.84, 95%CI = 1.35 – 2.52) mortality compared to patients with high-normal BMI (22.5–24.9 kg/m2). For overweight patients (BMI 25.0 – 29.9), the respective HRs were 1.29 (95%CI = 1.05 – 1.58) and 1.47 (95%CI = 1.14 – 1.89). Stratification by NHL type suggested higher NHL-specific mortality risk for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) than for diffuse large B-cell lymphoma (DLBCL). CONCLUSIONS: Pre-diagnostic obesity may be related to poorer overall and NHL-specific survival in NHL patients. Therefore, pre-diagnostic BMI may be a suitable prognostic marker for NHL patients.
Source: Europe PMC (PubMed Central)
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W217568939
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