Year: 2015
Type: article
Study design: Clinical Trial
Abstract: OBJECTIVE: Sleep curtailment has been linked to obesity, but underlying mechanisms remain to be elucidated. This study assessed whether sleep restriction alters 24-h profiles of appetite-regulating hormones ghrelin, leptin, and pancreatic polypeptide during a standardized diet and whether these hormonal alterations predict food intake during ad libitum feeding. METHODS: Nineteen healthy, lean men were studied under normal sleep and sleep restriction in a randomized crossover design. Blood samples were collected for 24 h during standardized meals. Subsequently, participants had an ad libitum feeding opportunity (buffet meals and snacks) and caloric intake was measured. RESULTS: Ghrelin levels were increased after sleep restriction as compared with normal sleep (P < 0.01). Overall, sleep restriction did not alter leptin or pancreatic polypeptide profiles. Sleep restriction was associated with an increase in total calories from snacks by 328 ± 140 kcal (P = 0.03), primarily from carbohydrates (P = 0.02). The increase in evening ghrelin during sleep restriction was correlated with higher consumption of calories from sweets (r = 0.48, P = 0.04). CONCLUSIONS: Sleep restriction as compared with normal sleep significantly increases ghrelin levels. The increase in ghrelin is associated with higher consumption of calories. Elevated ghrelin may be a mechanism by which sleep loss leads to increased food intake and the development of obesity.
Source: Obesity
DOI: 10.1002/oby.21321
Authors: Josiane L. Broussard, Jennifer M. Kilkus, Fanny Delebecque, Varghese Abraham, Andrew Day, Harry R. Whitmore, Esra Tasali
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funders: U.S. Department of Defense, University of Chicago, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G18062229, G189463082, G2021055342, G211857436, G331478883, Sex steroids, Sleep, and Metabolic Dysfunction in Women, G4119534169, G4330944716, Alterations of Sleep and Circadian Timing in Aging, Pathways Linking Reduced Sleep Duration and Quality to Obesity Risk, G5850682332, G5935083311, G6743951032, G8631870757, G898378059, G9000015117, G9000058527, G9000334782
OpenAlex ID: W2175844293