Work

Thieme Chemistry Journal Awardees- Where are They Now? Intermolecular Cross-Acyloin Reactions by Fluoride-Promoted Additions of O-Silyl Thiazolium Carbinols

Year: 2009

Type: article

Abstract: The addition of acyl anion equivalents to aliphatic aldehydes (crossed-acyloin reaction) has been developed. Cesium fluoride with isopropanol as solvent promotes the addition of O-silyl thiazolium carbinols to various aliphatic aldehydes in moderate to good yields. These reactions represent a general procedure for the selective coupling of aliphatic aldehydes by an acyl anion reaction which have been problematic until now.

Source: Synlett

DOI: 10.1055/s-0028-1087555

Authors: Karl Scheidt, Alex Mathies, Anita Mattson

Institution: Northwestern University

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Alfred P. Sloan Foundation, Eli Lilly and Company, ACS Division of Organic Chemistry, National Institute of General Medical Sciences

Award: G682315649