Work

New insights into microRNAs in skin wound healing

Year: 2015

Type: review

Abstract: Chronic wounds are a major burden to overall healthcare cost and patient morbidity. Chronic wounds affect a large portion of the US, and billions of healthcare dollars are spent in their treatment and management. microRNAs (miRNAs) are small, noncoding double-stranded RNAs that post-transcriptionally downregulate the expression of protein-coding genes. Studies have identified miRNAs involved in all three phases of wound healing including inflammation, proliferation, and remodeling. Some miRNAs have been demonstrated in vitro with primary keratinocyte wound healing model and in vivo with mouse wound healing model through regulation of miRNA expression to affect the wound healing process. This review updates the current miRNAs involved in wound healing and discusses the future therapeutic implications and research directions.

Source: IUBMB Life

DOI: 10.1002/iub.1449

Authors: Fatima Fahs, Xinling Bi, Fu-Shin Yu, Li Zhou, Qing-Sheng Mi

Institutions: Henry Ford Health, Oakland University, Henry Ford Hospital, Changhai Hospital, Wayne State University

Language: English

Topic: Wound Healing and Treatments

Subfield: Rehabilitation

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: Henry Ford Health System