Year: 2015
Type: article
Study design: Observational Study
Abstract: We surveyed 26 quantitative traits and disease outcomes to understand the proportion of phenotypic variance explained by local ancestry in admixed African Americans. After inferring local ancestry as the number of African-ancestry chromosomes at hundreds of thousands of genotyped loci across all autosomes, we used a linear mixed effects model to estimate the variance explained by local ancestry in two large independent samples of unrelated African Americans. We found that local ancestry at major and polygenic effect genes can explain up to 20 and 8% of phenotypic variance, respectively. These findings provide evidence that most but not all additive genetic variance is explained by genetic markers undifferentiated by ancestry. These results also inform the proportion of health disparities due to genetic risk factors and the magnitude of error in association studies not controlling for local ancestry.
Source: Frontiers in Genetics
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Institute on Minority Health and Health Disparities
Awards: G1052397333, G1243299691, G1460387277, G1527150935, The Howard University SCORE Program, G1691174148, G173303992, G3114902838, G3152385821, G3462919067, GWA for Gene-Environment Interaction Effects Influencing CHD, G4167445418, G4200864717, Howard University General Clinical Research Center, G5074086979, G567847597, G6195637971, Eliminating Health Disparities Through Multi-Trans-Disciplinary Approaches, G6552090923, Genetic epidemiology of complex diseases
OpenAlex ID: W2176986943