Work

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes

Year: 2015

Type: article

Abstract: The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.

Source: Chemical Communications

DOI: 10.1039/c5cc07792c

Authors: Amit S. Pithadia, Anirban Bhunia, Rajendran Sribalan, Vediappen Padmini, Carol A. Fierke, Ayyalusamy Ramamoorthy

Institutions: University of Michigan, Bose Institute, Madurai Kamaraj University

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Institute of General Medical Sciences