Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Year: 2005
Type: article
Study design: Observational Study
Abstract: Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood; and adolescence. We measured serum levels of IGF-I, IGFBP-2 and IGFBP-3 by enzyme-linked immunosorbent assay(ELISA) and analysed the serum levels according to sex and age group. Results : For boys, the mean serum levels of IGF-I(ng/mL) in neonate, infancy, early childhood, late childhood and adolescence were 41.1±3.6, 70.9±33.7, 103.5±97.2, 89.8±46.5 and 51.4±27.8, respectively. Those of IGFBP-2(ng/mL) were 8.2±3.4, 5.8±0.4, 9.3±4.0, 9.5±1.1 and 7.0±0.5, respectively. Those of IGFBP-3(ng/mL) were 559.2±215.2, 1,333.3±692.5, 2,254.6±1,513.8, 2,447.1±1,464.2, 1,533.6± 807.4, respectively. For girls, the mean serum levels of IGF-I(ng/mL) according to five age groups were 53.3±9.5, 99.3±45.8, 69.6±51.1, 106.2±67.0 and 145.1±127.8, respectively. Those of IGFBP-2 (ng/mL) were 9.1±7.4, 5.3±0.9, 6.9±2.0, 10.5±3.0 and 7.9±1.3, respectively. Those of IGFBP-3(ng/ mL) were 858.2±433.4, 1,834.8±851.3, 1,404.3±570.2, 2,203.5±899.4 and 2,029.3±1,316.7, respectively. There were significant positive correlations observed between IGF-I and IGFBP-3 levels(r=0.589, P= 0.000). Conclusion : IGF-I and IGFBP-3 levels increased as children get older. The peak level of IGFBP-3 was observed in late childhood for both boys and girls, suggesting a current trend of children reaching peak growth velocity before adolescence. The IGFBP-2 level was higher in neonates compare to infancy, suggesting that IGFBP-2 is an important substance for fetal growth. (Korean J Pediatr 2005;48:298-305)
Source: Korean Journal of Pediatrics
Institutions: Kangbuk Samsung Hospital, Sungkyunkwan University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2178205578