Work

Bew Beauveriolides Produced by Amino Acid-supplemented Fermentation of Beauveria sp. FO-6979.

Year: 2004

Type: article

Abstract: Five new beauveriolides were isolated from the acetone extracts of Beauveria sp. FO-6979 mycelia fermented in amino acid-supplemented media. The structures were elucidated by spectroscopic studies including NMR experiments and chemical degradation. All the beauveriolides are cyclodepsipeptides consisting of one 3-hydroxy-4-methyl fatty acid, two L-amino acids and one D-amino acid in common. Beauveriolide VII with the structure of cyclo-[3-hydroxy-4-methyloctanoyl-L-phenylalanyl-L-alanyl-D-valyl] inhibited lipid droplet formation and cholesteryl ester synthesis in macrophages, but the other beauveriolides showed only slight or almost no effect on lipid droplet formation.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.57.1

Authors: DAISUKE MATSUDA, ICHIJI NAMATAME, HIROSHI TOMODA, SUSUMU KOBAYASHI, RAINER ZOCHER, HORST KLEINKAUF, SATOSHI OMURA

Institutions: Tokyo University of Science, Kitasato University, Japan Society for the Promotion of Science, Technische Universität Berlin

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

Funders: Ministry of Education, Culture, Sports, Science and Technology, Japan Society for the Promotion of Science

OpenAlex ID: W2178673777

FWCI: 3.212

Cites: 9

Cited by: 51

Related to: 10