Work

Agonist anti-4-1BB plus neutralizing anti-CTLA-4 or -PD-L1 synergize to promote tumor regression by rescuing dying dysfunctional CD8+ T cells within the tumor microenvironment

Year: 2015

Type: article

Abstract: Meeting abstracts Tumors can be broadly placed into two categories: those that are T cell-inflamed and those that are not, with T cell-inflamed tumors having specific chemokine and type I interferon gene expression signatures as well as CD8+ tumor-infiltrating T cells (TIL). The fact that these T

Source: Journal for ImmunoTherapy of Cancer

DOI: 10.1186/2051-1426-3-s2-o10

Authors: Brendan Horton, Jason B Williams, Stefani Spranger, Thomas F Gajewski

Institution: University of Chicago

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,490