Year: 2015
Type: article
Abstract: Differentiation of T cells is closely associated with dynamic changes in nutrient and energy metabolism. However, the extent to which specific metabolic pathways and molecular components are determinative of CD8+ T cell fate remains unclear. It has been previously established in various tissues that acetyl CoA carboxylase 2 (ACC2) regulates fatty acid oxidation (FAO) by inhibiting carnitine palmitoyltransferase 1 (CPT1), a rate-limiting enzyme of FAO in mitochondria. Here, we explore the cell-intrinsic role of ACC2 in T cell immunity in response to infections. We report here that ACC2 deficiency results in a marginal increase of cellular FAO in CD8+ T cells, but does not appear to influence antigen-specific effector and memory CD8+ T cell responses during infection with listeria or lymphocytic choriomeningitis virus. These results suggest that ACC2 is dispensable for CD8+ T cell responses.
Source: PLoS ONE
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,382
Awards: G1189622924, G1194463175, Interaction between microbiota and dendritic cells in mucosal tolerance, Cellular and transcriptional control of exhausted CD8 T cells lineage dynamics, G2257773966, G2626054926, G3073074070, G5764297854, Mechanisms and Immunological Consequences of Host-Virus Interactions, G7997375432, TRAF6 and the Fate of CD8 T Cells, G8341471131, G9000112183, G9000178764, Regulation of mucosal immunity by neuronal pathways, Durable Alteration of the Human Immune system after Infection or Immunotherapy
OpenAlex ID: W2179845077