Evaluation of Osteoprotegerin Levels in Patients with Coronary Artery Disease
Year: 2015
Type: article
Study design: Observational Study
Abstract: Background: Osteoprotegerin (OPG) is classed as an osteoclastogenesis inhibitory factor plays an important regulatory role in the skeletal, immune, and vascular systems.OPG acts as a soluble decoy receptor for receptor activator of nuclear factor-kabba Bligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL). OPG has been identified as a survival factor for endothelial cells and vascular smooth muscle cell (VSMC). Atherosclerosis is the most frequent underlying cause of coronary artery disease (CAD), carotid artery disease and peripheral artery disease. It appears that OPG is able to prevent, but not reverse, the process of vascular calcification. The aimof this study to determine the possible association of OPG with coronary artery disease and to detect early subclinical arthrosclerosis. Subjects and methods: the study was conducted on seventy subjects, suffering from chest pain and underwent diagnostic coronary angiography. On the basis of coronary angiography the present study was conducted on seventy subjects are arranged into 4 groups:20patients with one stenotic vessel (group II). 15 patients with two stenotic vessels (group III). 20 patients with three stenotic vessels (group IV) as well as fifty apparently healthy control (gruop I). All subjects included in this study were subjected to the following: Full history taking, clinical examination, laboratory investigations including fasting blood glucose levels and lipid profile (LDL, HDL, total cholesterol and triglycerides). in addition, specific investigations which include serum ostoprotegerinlevel by ELISA technique and serum CRP by latex serology testwere done.Results: it was found that all patients have significantly higher serum OPG level (p≤ 0.05) . The higher serum OPG levels were observedin the group with three stenotic vesselcompared with the groups with one-stenotic vessel, towstenotic vessel and conrol. Significant positive correlation was found between serum OPG and age. Conclusion: present study revealed an association between OPG and the number of stenotic vessels. This means that, OPG level might a marker for coronary artery disease severtyalso, it is a simple adjuvant to other noninvasive diagnosticmodalities of coronary atery disease.
Source: American Journal of Biochemistry
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2180749986