Year: 2015
Type: dissertation
Abstract: \n \nRegulation of gene expression is necessary for the control of complex developmental processes. The genome has to shape in specific conformations to fit inside the nucleus and to tether specific regulatory elements to their target genes. Although the linear composition of many genomes is largely known, their three dimensional (3D) organization and dynamics are largely unknown. Hence, in order to unravel gene regulation, it is necessary to understand the chromatin structure and organization. Furthermore, developmental procedures are controlled by complex combinatorial transcription factor (TF) networks. Hence, unveiling those networks will provide a better insight towards understanding those developmental procedures. The work described in this thesis aims to study the genome conformation/interactome and their effect on gene regulation and to unveil the role of transcription factor proteins (TFs) in complex developmental processes.
Author: Petros Kolovos
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funders: E-Rare, Koninklijke Nederlandse Akademie van Wetenschappen, Bundesministerium für Bildung und Forschung, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Ministerio de Economía y Competitividad, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Biotechnology and Biological Sciences Research Council
OpenAlex ID: W2180990081