Where Is the Semantic System? A Critical Review and Meta-Analysis of 120 Functional Neuroimaging Studies
Year: 2009
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Semantic memory refers to knowledge about people, objects, actions, relations, self, and culture acquired through experience. The neural systems that store and retrieve this information have been studied for many years, but a consensus regarding their identity has not been reached. Using strict inclusion criteria, we analyzed 120 functional neuroimaging studies focusing on semantic processing. Reliable areas of activation in these studies were identified using the activation likelihood estimate (ALE) technique. These activations formed a distinct, left-lateralized network comprised of 7 regions: posterior inferior parietal lobe, middle temporal gyrus, fusiform and parahippocampal gyri, dorsomedial prefrontal cortex, inferior frontal gyrus, ventromedial prefrontal cortex, and posterior cingulate gyrus. Secondary analyses showed specific subregions of this network associated with knowledge of actions, manipulable artifacts, abstract concepts, and concrete concepts. The cortical regions involved in semantic processing can be grouped into 3 broad categories: posterior multimodal and heteromodal association cortex, heteromodal prefrontal cortex, and medial limbic regions. The expansion of these regions in the human relative to the nonhuman primate brain may explain uniquely human capacities to use language productively, plan, solve problems, and create cultural and technological artifacts, all of which depend on the fluid and efficient retrieval and manipulation of semantic knowledge.
Source: Cerebral Cortex
Institution: Medical College of Wisconsin
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Awards: Functional MRI of Human Brain Language Systems, Functional MRI of Sensory-Motor Metaphor Processing, Training in Functional Neuroimaging, Presurgical Applications of FMRI in Epilepsy, Combining artificial neural network models and fMRI to study brain and language, Neurophysiological basis of speech perception
OpenAlex ID: W2112891119