Changes in ≈lastin Turnover in Patients With Different Types of Hydatid Disease (echinococcosis)
Year: 2009
Type: article
Study design: Observational Study
Abstract: Echinococcosis is a serious parasitic disease in animals and human beings. Echinococcus granulosus grows very slowly and can be localized in different organs, where it damages both specific structure and elastic fibres of the organ concerned. The aim of this study was to assess elastin turnover via changes in levels of specific antielastin antibodies (AEAbs) of different immunoglobulin classes (IgM, IgA, IgG) and IgG subclasses in sera of patients suffering from different types of hydatid disease, and to establish a possible relationship between these levels and the severity of the disease. Anti-human IgM, IgA, IgG peroxidase immunoconjugates and monoclonal IgG subclasses were used to carry out enzyme-linked immunosorbent assay (ELISA). We studied sera from 18 patients with hydatid disease (mean age 42.5 yrs; 16-72yrs; 14 females and 4 males) operated on at Surgery Clinic I, University Hospital, or seen at the parasitology consulting room of the hospital. The diagnoses were confirmed serologically and surgically in all 11 patients with liver echinococcosis. In those with lung and multiple/multiorgan hydatid disease, the diagnoses were additionally confirmed by chest X-ray, computed tomography (CT) and ultrasound imaging. Significant differences with the controls were found for antielastin IgA (p<0.001) and IgM (p<0.01), most expressed in patients with lung and multiple/multiorgan echinococcosis. Antielastin IgG , IgG and IgG levels in the patients investigated did not 1 2 3 show significant differences from levels found in controls, except for isotype AEIgG . This isotype was prevalent in 4 patients with lung and multiple/multiorgan echinococcosis (p<0.01). Our results indicate increased elastin turnover that points to a likely relationship between the levels of AEAbs IgA, IgM and IgG and localization and dissemination of E. 4 granulosus, which relationship might be of interest for clinical practice.
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2181422617