Relación entre ácido úrico y estrés oxidativo en pacientes con síndrome metabólico
Year: 2008
Type: dissertation
Study design: Observational Study
Abstract: Metabolic syndrome (MS) is a set of risk factors for developing type 2 diabetes mellitus (MTD 2) and cardiovascular disease, characterized by insulin resistance and hyperinsulinism compensator, disorders associated with the metabolism of carbohydrates and lipids, hypertension blood, and obesity. Were selected 200 adults (50 men and 50 women) [(diabetics with hypertension (n = 35), diabetics (31) and hypertensive (n = 34)] aged between 20 and 80 years, diagnosed with SM criteria according to NCEP / ATP III and fulfil 3 or more of the following conditions: abdominal adiposity defined, low HDL-c, hypertriglyceridemia, hypertension, abnormal glucose homeostasis. In addition, it was valued Col-T, LDL-C, Apo B100, uric acid and some markers of oxidative stress: total antioxidants (TAS), activities of enzymes erythrocytes (U/L) superoxide dismutase (CuZn-SOD) and glutathione peroxidase (Se-GPx), and comparing their activity with the concentration of hemoglobin (U/gHB) and subsequently found the balance between cellular antioxidant enzymes by the rules of Chebyshev. The control group was formed by a similar number, gender and age, selected at random. With the results was conducted estimating parameters each group (MS and controls) and confidence intervals of 95% for the average population, the Student t test mean differences assuming unequal variances and analysis of variance was significant p <0.05. There were significant differences between patients and controls being inherent in the MS, independent of gender. There hyperuricemia in patients with MS, however we found no differences in relation to gender. This behavior can be a reflection of change paradoxical that the experiment uric acid as antioxidant agent to prooxidante. We found decrease markers of oxidative stress due to the possible generation of ROS which leads to disbalance of the antioxidant system.
Language: Spanish
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2181475979