Regulation of male germ cell apoptosis : Roles of sex steroids and the cellular death receptors Fas and TNFR1
Year: 2002
Type: dissertation
Abstract: 8 INTRODUCTION 10 REVIEW OF THE LITERATURE 11 Spermatogenesis 11 Development of the testis 11 Adult spermatogenesis 11 Apoptotic cell death in the testis 14 Apoptosis 14 Caspase activation 14 Intracellular regulators of apoptosis 15 Caspase-independent apoptosis 17 Germ cell apoptosis 18 Physiological germ cell apoptosis 18 Inappropriate germ cell apoptosis 18 Hormonal control of germ cell apoptosis 19 Gonadotropins and androgens 19 Estrogens 20 Apoptosis control by the death receptors Fas and TNFR1 21 Death receptors and ligands 21 Mechanisms for the regulation of apoptosis by Fas and TNFR1 22 Physiological roles of the FasLand TNFαinduced signaling 24 The Fas system in the testis 25 Testicular production and effects of TNFα 25 Nuclear factor κB (NF-κB) 26 NF-κB/Rel and IκB proteins 26 Activation and target genes of NF-κB 26 Regulation of apoptosis by NF-κB 28 NF-κB in the testis 28 AIMS OF THE STUDY 30 MATERIALS AND METHODS Patients 31 Tissue culture and treatments 31 Laboratory analyses 31 Southern blot analysis of DNA fragmentation 31
Source: Työväentutkimus Vuosikirja
Author: Pentikäinen, Virve
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2181483607