Work

Lipolytic activity of post-heparin plasma in hyperglyceridemia

Year: 1963

Type: article

Abstract: A standard assay has been developed for the lipolytic activity of post-heparin plasma permitting rate measurements with zero order kinetics over wide ranges of enzymatic activity and concentrations of plasma glycerides. Measurements were made in 60 subjects with hyperglyceridemia, 18 of whom had been further subclassified by dietary studies into either fat-induced or carbohydrate-induced types. Activity in the majority of subjects with hyperglyceridemia, including all of the carbohydrate-induced type, was equal to or greater than that found in normal subjects. Subjects with fat-induced hyperglyceridemia, with one exception, and some of their relatives had abnormally low values. The level of activity in both normal and hyperglyceridemic subjects was uniformly dependent upon prior dietary fat intake.

Source: Journal of Lipid Research

DOI: 10.1016/s0022-2275(20)40361-x

Authors: Donald S. Fredrickson, Katsuto Ono, Louis L. Davis

Institution: National Institutes of Health

Language: English

Topic: Lipid metabolism and disorders

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,430