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Modulating immunometabolism of tumor specific mouse and human lymphocytes to enhance T cell based therapy for cancer

Year: 2015
Type: article
Abstract: Meeting abstracts Tumor cells and tumor infiltrating lymphocytes (TIL) competes for glucose and other metabolites within the tumor microenvironment for their survival. Glucose consumption by tumors metabolically restricts T cell's ability to produce effector cytokines and therefore approaches to
DOI: 10.1186/2051-1426-3-s2-p325
Authors: Madhusudhanan Sukumar, Jie Liu, Shashank J Patel, Christopher A Klebanoff, Gautam Mehta, Rahul Roychoudhuri, Joseph Crompton, David Clever, Luca Gattinoni, Pawel Muranski, Toren Finkel, Nicholas Restifo
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,490
OpenAlex ID: W2182002985
FWCI:
Cites:
Cited by: 1
Related to: 10