Epigenetic regulation of PGC1 in human type 2 diabetes
Year: 2013
Type: article
Abstract: Type 2 diabetes mellitus (T2DM) is the most common metabolic disease in the world, reaching epidemic proportions. PPARGC1A mRNA expression is reduced in islets from patients with diabetes 2 and it is influenced by both genetic and epigenetic factor. The epigenetic modification, results as a two fold increase in DNA methylation of the PGC1A promoter of diabetes. This two fold increase in DNA methylation is due to the DNA methyl transferase1 (DNMT1) enzyme. In the present study, methylation activity of DNMT 1 enzyme was inhibited with suitable methylation inhibitors which led to the decrease of the hypermethylation of PGC 1 alpha protein. The interaction study of this modified DNMT1 with PGC 1 alpha leads to the new way of drug discovery in type 2 diabetes.
DOI: 10.5897/jbsb11.002
Author: Y. Dhanusha Yesudhas
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2182071468