Work

Review paper Apolipoprotein E knockout mice:an experimental model to study inflammatorymechanisms of atherosclerosis and to screena putative anti-atherogenic properties of drugs

Year: 2012

Type: article

Abstract: Based on the current knowledge it is well ascertained that inflammation backgrounds the pathogenesis of atherosclerosis. Still, some open questions remain.Animal model is an important tool to study atherogenesis.Nowadays, genetically modified mice play a pivotal role.Wild mice are highly resistant to atherosclerosis, whereas "gene-targeted" modified mice can spontaneously (even without use of high cholesterol diet) develop atherosclerosis.The best example are apolipoprotein E (apoE)-knockout mice.In this review we will discuss usefulness of apoE-knockout mice to study the pathogenesis of atherosclerotic lesions, especially the immune mechanisms of atherogenesis.

Source: Jagiellonian University Repository (Jagiellonian University)

Authors: Jacek Jawień, Rafał Olszanecki, Bernadeta Nowak, Janusz Marcinkiewicz

Institution: Akademickie Centrum Komputerowe Cyfronet AGH

Language: English

Topic: Atherosclerosis and Cardiovascular Diseases

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2182270260

FWCI: 0.519

Cites: 74

Cited by: 4

Related to: 10