Formulation and Characterization of Carvedilol Nanoemulsion Oral Liquid Dosage Form
Year: 2015
Type: article
Abstract: Objective: Carvedilol is antihypertensive. It is practically water insoluble. Therefore, the objective of this investigation is a formulation and characterization of carvedilol nano emulsion (NE) employing orally to increase carvedilol solubility for enhancing of carvedilol bioavailability. Methods: The formulation components were chosen according to the solubility study. The diagrams of pseudo-ternary phase were made using the aqueous phase titration method. The formulated nanoemulsions were subjected to various thermodynamic stability assays. We selected eight of formulas that have thermodynamic stability for further optimization for various characterizations in order to select the best formula. Results: The carvedilol NE3 considered a selected formula. It composes of 1.25 mg carvedilol per g of the nanoemulsion, 10 % of peppermint oil, 20% of tween80, 10% ethanol and 60% of distilled water. It was characterized by a low globule size range, low poly dispersity index, higher zeta potential, good pH value, efficient electroconductivity, classy percent of light transmittance, higher % drug content, acceptable low viscosity and carvedilol release was significantly higher (P<0.05) in dissolution rate. The carvedilol NE3 subject for further investigations. Fourier transformed infrared spectroscopy confirm no incompatibility between the drug and excipients. The atomic force microscopy study shows that system in nanoscale and has high stability. Conclusion: The selected formula (carvedilol NE3) was a promising nanoemulsion formula that increases the carvedilol solubility result in an increment of its bioavailability.
Authors: Hayder Kadhim Drais, Ahmed A. Hussein
Institutions: University of Baghdad, Ministry of Health
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2182426747