Year: 2014
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Cardiovascular diseases are frequent and a major cause of death in patients with chronic obstructive pulmonary disease (COPD). In the general population, various fat depots including abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and liver fat have been linked to increased risk of cardiovascular diseases. We hypothesize that these adipose tissue compartments are associated with myocardial infarction (MI) in patients with COPD. METHODS: We collected measures of VAT and SAT areas and liver attenuation on the computed tomography scan of the chest from 1267 patients with COPD. MI was a self-reported physician-diagnosed outcome. The association between fat depots and self-reported history of MI was assessed by logistic regression analysis in which the patients within the 2 lowest tertiles of VAT and SAT areas were the reference group. RESULTS: ; P=0.002) with no differences in SAT area and liver fat. After adjustment for age, gender, obesity, pack years of smoking, hypertension, high cholesterol, and diabetes, patients within the upper tertile (vs. those in the lower tertiles) of VAT area had increased odds of MI (odds ratio [OR] 1.86, 95% confidence interval [CI] 1.02 - 3.41). CONCLUSION: Increased abdominal visceral fat is independently associated with a history of MI in individuals with COPD.
Authors: Rosa Faner, Alvar Agusti
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Computed Tomographic characterization of subjects enrolled in the STATCOPE trial, (2 of 2) Genetic Epidemiology of COPD, The clinical impact of longitudinal measures of cardiac and pulmonary vascular morphology in smokers, CT-based Phenotype for Airway Remodeling in COPD based on Airway Wall Density, (1 of 2) Genetic Epidemiology of COPD, (2 of 2) Genetic Epidemiology of COPD, (1 of 2) Genetic Epidemiology of COPD, Computed Tomographic-Based Assessment of Airway Remodeling in COPD, Airway Inspector: a chest imaging biomarker software platform for COPD
OpenAlex ID: W2181595278