Work

Molecular Pathogenesis of Sporadic Melanoma and Melanoma-Initiating Cells

Year: 2010

Type: article

Abstract: Recent advances in molecular genetics and cancer stem cell biology have shed some light on the molecular basis of melanomagenesis. In this review, we will focus on major genetic alterations in the melanoma, particularly pathways involved in cell proliferation, apoptosis, and tumor suppression. The potential role of melanoma-initiating cells during melanomagenesis and progression will also be discussed. Understanding pathogenesis of melanoma may uncover new diagnostic clues and therapeutic targets for this increasingly prevalent disease.

Source: Archives of Pathology & Laboratory Medicine

DOI: 10.5858/2009-0418-rar.1

Authors: Yunyi Kong, Suresh M. Kumar, Xiaowei Xu

Institutions: Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center

Language: English

Topic: Melanoma and MAPK Pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases