Year: 2014
Type: article
Abstract: The immune system in the intestine represents a unique environment that can quickly respond to harmful pathogens, but it remains tolerant to antigens from food and commensal bacteria.This balance between protective immunity and tolerance is largely dependent on the mononuclear phagocytes in the intestine, such as macrophages.Intestinal macrophages, unlike other macrophage populations in the body, are hypo-responsive to stimuli although they originate from fully responsive blood monocytes.The intestinal environment seems to instruct monocytes to mute their function upon arrival to the gut in order to adapt to the antigen-rich environment.While their main role in the healthy gut is to maintain homeostasis, in disease macrophage phenotype and function is changed and these cells become the drivers of inflammation and disease progression. INTRoduCTIoN
Authors: Maja Kristek, Christine E. Loscher
Institution: Dublin City University
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: G3207356259, G496129201
OpenAlex ID: W2182934073