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Exploring the Potential of Transient Receptor Potential: Troubleshooting Troublesome Calcium Thoroughfares in Biomedicine

Year: 2010

Type: article

Abstract: Transient Receptor Potential-Canonical (TRPC) channels are the border guards residing in the supra-molecular assembly of plasma membrane. TRPCs represent a family of channels that have dual functions of store-operated and second messenger-operated channels in a diversity of cell types. Any disruption in the spatio-temporal organization drastically influences the calcium homeostasis. This review summarizes current interpretations on the infrastructure and characteristic divalent ions regulation in molecular anomalies. A specific targeting of these channels will enable us to get a step closer to personalized medicines.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Ammad Ahmad Farooqi, Abuzar Kaleem, Muhammad Khalid Javeed, Qaisar Mansoor, Shahzad Bhatti

Language: English

Topic: Ion Channels and Receptors

Subfield: Sensory Systems

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W2182948424

FWCI:

Cites: 82

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Related to: 10