Work

The Effect of Some Cosolvents and Surfactants on Viability of Cancerous Cell Lines

Year: 2014

Type: article

Abstract: Improving the solubility of non-soluble herbal materials is an issue of interest in cell culture based experiments. Evaluating the biological activity of these materials could become possible with the aid of cosolvents/surfactants which obviously should have little or no cytotoxic activity. In the present study, the cytotoxic activity of six cosolvents/surfactants: ethanol, methanol, Tween 20 and 80, propylene glycol (PG) and poly ethylene glycol 400 (PEG) which are usually helpful in dissolving non-soluble herbal extracts, has been evaluated against HepG-2, MCF-7 and HT-29 cells by MTT assay. Among the investigated cosolvents/surfactants, Tween 20 and 80 demonstrated the highest and ethanol and methanol the lowest cytotoxicity to the evaluated cell lines, suggesting the two latter as proper aids for improving solubility in biological experiments.

Source: DOAJ (DOAJ: Directory of Open Access Journals)

Authors: Maryam Hamzeloo‐Moghadam, N Taiebi, Mahmoud Mosaddegh, B. Eslami Tehrani, Somayeh Esmaeili

Institutions: Shahid Beheshti University of Medical Sciences, Islamic Azad University, Tehran, Islamic Azad University Pharmaceutical Sciences Branch, Shahid Beheshti University

Language: English

Topic: Phytochemical Studies and Bioactivities

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2183216594

FWCI: 0.137

Cites: 12

Cited by: 18

Related to: 10