Work

BRCA1: A Missing Link in the Fanconi Anemia/BRCA Pathway

Year: 2013

Type: article

Abstract: Summary: Domchek and colleagues provide a case report of a 28-year-old woman with congenital abnormalities, inherited ovarian cancer, and carboplatin hypersensitivity. Interestingly, the woman had validated germline mutations in both BRCA1 alleles. These findings further implicate BRCA1 in the Fanconi anemia/BRCA pathway and have important implications for BRCA1 genetic testing. Cancer Discov; 3(4); 376–8. ©2013 AACR. See related article by Domchek et al., p. 399

Source: Cancer Discovery

DOI: 10.1158/2159-8290.cd-13-0044

Author: Alan D. D'Andrea

Institutions: Harvard University, Dana-Farber Cancer Institute

Language: English

Topic: BRCA gene mutations in cancer

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases