Work

Spinal cord injury as a trigger to develop periodic leg movements during sleep: an evolutionary perspective

Year: 2012

Type: article

Abstract: The primary trigger to periodic limb movement (PLM) during sleep is still unknown. Its association with the restless legs syndrome (RLS) is established in humans and was reported in spinal cord injury (SCI) patients classified by the American Spinal Injury Association (ASIA) as A. Its pathogenesis has not been completely unraveled, though recent advances might enhance our knowledge about those malfunctions. PLM association with central pattern generator (CPG) is one of the possible pathologic mechanisms involved. This article reviewed the advances in PLM and RLS genetics, the evolution of CPG functioning, and the neurotransmitters involved in CPG, PLM and RLS. We have proposed that SCI might be a trigger to develop PLM.

Source: Arquivos de Neuro-Psiquiatria

DOI: 10.1590/s0004-282x2012001100011

Authors: Susana Cristina Lerosa Telles, Rosana S. Cardoso Alves, Gerson Chadi

Institution: Universidade de São Paulo

Language: English

Topic: Restless Legs Syndrome Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200