Cyclooxygenase-2, Prostaglandins, and Colorectal Carcinogenesis
Year: 2003
Type: book-chapter
Abstract: Despite significant progress in understanding the molecular basis of colorectal cancer, the disease remains a major global health problem that leads to approx 550,00 annual deaths worldwide. This failure in treatment has led to a search for novel, nontoxic agents that could possibly be utilized to prevent the development of the disease. Recently, inhibitors of the cyclooxygenase-2 (COX-2) enzyme have emerged as a class of drugs that may represent a viable approach for the chemoprevention of colorectal cancer. This chapter will begin with a review of some of the key findings that led to the hypothesis that COX-2 inhibitor therapy inhibits colorectal cancer development followed by a discussion of the prostaglandin (PG) signaling pathways that have been linked to the carcinogenic process.
Source: Humana Press eBooks
Authors: Rajnish A. Gupta, Raymond N. DuBois
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W2183901737