Year: 2015
Type: dissertation
Study design: Observational Study
Abstract: Ingested nitrate is a precursor of N-nitroso compounds that are carcinogens in animals, with limited evidence in humans. The main objective of this thesis was to evaluate whether the exposure to nitrate through drinking water and diet is associated with carcinogenic effects in humans. This thesis has been conducted in the Centre for Research in Environmental Epidemiology (CREAL) from 2011 to 2015, under the supervision of Cristina M. Villanueva Belmonte PhD. The results of this thesis consists of a compilation of four scientific papers including: a) a descriptive study of nitrate levels in drinking water in Spain (paper I), and b) three large European case-control studies evaluating the risk of prevalent tumors (bladder, breast and colorectal) associated with nitrate exposure through drinking water and diet (papers II, III and IV). This document also includes a general introduction, a description of the methodology, an overall discussion of the results, conclusions and an appendix section.
Authors: E. Hernández Herrera, Nadia Carminia
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2183964038