V1a vasopressin receptor gene single nucleotide polymorphism and essential hypertension, type 2 diabetes mellitus and platelet aggregation
Year: 2007
Type: article
Study design: Observational Study
Abstract: Candidate gene SNP study is a promising genetic approaches to complex common disorders. Arginine\nvasopressin （AVP）, a peptide hormone released from the posterior pituitary, has been suggested to play important\nroles in the regulation of blood pressure, glycogenolysis and platelet aggregation through G protein coupled V1a\nreceptor （V1aR）. Thus, polymorphisms in the V1aR gene have been prospective as possible genetic markers for\nessential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identifi ed 4\nnovel single nucleotide polymorphisms（ SNPs） in the promoter region of the V1aR gene and named according to the\nupstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs of\nthe V1aR gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects\n（CS）, and 33 young healthy volunteers living in the Aomori prefecture. Signifi cant association was identifi ed between\nSNP at -6951 and hypertension in nonobese individuals, at -6951 and type 2 diabetes mellitus. Positive association was\nalso identifi ed between nonobese hypertension and haplotype H3. Signifi cant association was demonstrated between\nSNP at -6951 and glycemic status in young healthy subjects. However, there was no signifi cant association in the AVPinduced\nplatelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as increased risk\nfor hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, might not be useful as\ngenetic markers for platelet aggregation heterogeneity.
Institution: Hirosaki University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2184093343