Sex-Based Differences in Causes of Hospitalization for Coronary Heart Disease
Year: 2000
Type: article
Study design: Observational Study
Abstract: To evaluate sex-based difference in clinical manifestations of coronary heart disease (CHD), we prospectively studied sex and other predictors of hospitalization for CHD in 56,926 men (2802 cases) and 72,008 women (1449 cases) for whom baseline data were available from previous examinations. Cox models with ten covariates were used to study first hospital admission for CHD. In age-adjusted (AA) and multivariate (MV) analyses, men had substantially greater relative risk (RR) for acute myocardial infarction (ICD-9 code 410, n = 1757, AA RR = 2.6, MV RR = 2.7) and for chronic ischemic heart disease (ICD-9 codes 412, 414, n = 573, AA RR = 3.3, MV RR = 3.3) than for other acute syndromes (ICD-9 code 411, n = 848, AA RR = 1.6, MV RR = 1.5) or for angina (ICD-9 code 413, n = 753, AA RR = 1.6, MV RR = 1.6); all p values <0.001. Most CHD predictors were more strongly related to risk of coronary artery disease in women, but this relation was similar for the CHD diagnostic subsets. Risk of later death from CHD was similar for the sexes. These data show a major independent sex-based difference in CHD-related diagnoses leading to hospitalization : men are at greater risk for acute myocardial infarction, and women are at greater risk for stable or unstable angina.
Source: Europe PMC (PubMed Central)
Authors: Arthur L. Klatsky, Mary Anne Armstrong
Language: English
Topic: Sex and Gender in Healthcare
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2184262676