Work

Syzygium cumini (pomposia) active principles exhibit potent anticancer and antioxidant activities

Year: 2011

Type: article

Abstract: The antioxidant and anticancer activities of Syzygium cumini fruit extracts were investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical-scavenging assay and viability of leukemia cancer cells (AML cell line) respectively. The successive extracts, hexane, chloroform, ether, ethyl acetate, ethanol and water were prepared and subjected to antioxidant and anticancer evaluation. The results showed that the ethanol extract had stronger antioxidant and anti- leukemia activities than the other ones. Spectroscopic methods data of active ingredients separated from ethanol extract indicated that S. cumini fruit extracts contained phenolic compounds, such as Kaempferol 7-O-methylether and sterols such as γ-Sitosterol responsible for their antioxidant and anticancer activities. A significant linear relationship between anticancer potency, free radical-scavenging ability and the content of active compounds of fruit extracts supported this observation. Key words: Anticancer, antioxidant, successive extraction, Syzygium cumini.

Source: African Journal of Pharmacy and Pharmacology

Authors: Abd El-Moneim M. R. Afify, Sayed A. Fayed, Emad A. Shalaby, Hany A. El‐Shemy

Language: English

Topic: Medicinal Plant Research

Subfield: Plant Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2184295692

FWCI: 5.289

Cites: 28

Cited by: 67

Related to: 10