Work

Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications

Year: 2014

Type: article

Abstract: Post-translational protein modifications are a dynamic method of regulating protein function in response to environmental signals. As with any cellular process, T cell receptor (TCR) complex-mediated signaling is highly regulated, since the strength and duration of TCR-generated signals governs T cell development and activation. While regulation of TCR complex-mediated signaling by phosphorylation has been well studied, regulation by ubiquitin and ubiquitin-like modifiers is still an emerging area of investigation. This review will examine how ubiquitin, E3 ubiquitin ligases, and other ubiquitin-like modifications such as SUMO and NEDD8 regulate TCR complex-mediated signaling.

Source: Europe PMC (PubMed Central)

DOI: 10.25677/gwxq-0d13

Authors: Friend, Samantha F., Deason-Towne, Francina, Peterson, Lisa K., Berger, Allison J., Dragon, Leonard L.

Institutions: National Jewish Health, University of Colorado Anschutz, Regis University, University of Colorado Denver, Children's Hospital Colorado

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases