In Vitro Anti-viral Activity of Centella Asiatica L., Curcuma Longa L. and Strobilanthes Crispus L. Against Herpes Virus.
Year: 2014
Type: article
Abstract: Extracts of three different plant species; Curcuma longa L., Centella asiatica L. and Strobilanthes crispus L. which are used widely in Malaysian traditional medicine are investigated for antiviral activity against alpha-herpesvirus (pseudorabies virus). The methanol extract (ME) and aqueous extract (AE) were tested in three cell lines; African Green Monkey Kidney (Vero), Baby Hamster Kidney (BHK) and Rabbit Kidney (RK) cells, at non-cytotoxic concentrations. Assays were developed to determine the characteristics of anti pseudorabies virus (PrV) activities, as anti-viral attachment, anti-prophylactic and /or virucidal. All plant extracts showed marked virucidal ability and considerable prophylactic and anti-viral attachment activities. Plant ME always showed better antiviral activities than plant AE. Curcuma longa L. showed a better virucidal and prophylactic effect (with more than 70% cell viability at 25 μg/ml) for ME and AE. While Centella asiatica L. and Strobilanthes crispus L. were most active as anti-viral attachment agent with percent cell viability up to 60%. It was also found that the anti-viral activities were varies in different cell lines tested. Therefore, the extracts of all three plant species exhibited anti PrV and they could be further investigated for medical purposes.
Authors: H. Hanisa, Mas Suhaila
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2184396686