Total Antioxidant Capacity of Plasma Determined as Ferrous Reducing Ability of Plasma in Patients With Copd.
Year: 2010
Type: article
Study design: Observational Study
Abstract: The aim of the current study was to adapt a method for assessment of total antioxidant capacity of plasma by measuring the ferrous reducing activity of plasma (FRAP method), to determine factors affecting FRAP levels in patients with COPD and in control individuals, and to elucidate the possible effect of FRAP on lung function. Methods: The plasma total antioxidant capacity (TAC) was evaluated in 80 patients with COPD and in 20 non-affected control individuals by FRAP assay. Results: The plasma TAC of patients was significantly lower (0.936 mmol/l Fe 2+ ) than that of controls (1.110 mmol/l Fe 2+ ). When considered the smoking habits, we found that FRAP levels were significantly lower in patients who were current or ex-smokers compared to those who had never smoked (p=0.030). There was also a tendency for decrease of FRAP levels in patients with advance COPD stage (GOLD IV) than in those with GOLD II or III COPD, as well as in patients with earlier onset of the disease (<65 years). The FRAP levels negatively correlated with the body mass index, as this correlation was more notable in females, both patients and controls. Conclusions: The current results suggest the presence of systemic oxidative stress in COPD and confirm the role of smoking in its aggravation. The overweight might contribute to the deterioration of total antioxidant capacity of plasma especially in women, both with COPD and unaffected once.
Source: Trakia Journal of Sciences
Institution: Trakia University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2184422407