Year: 2005
Type: review
Abstract: The innate immune system senses invading microorganisms by a phylogenetically conserved family of proteins PRRs of which TLRs are ones of the most important. There are at least 10 different TLRs in humans and 11 in mice. They have in the course of evolution specialized for the recognition of conserved structures among microorganisms called PAMPs. Activation of TLRs results in induction of innate immunity mechanisms as well in development of antigen-specific adaptive immune responses, thus bridging innate and adaptive immunity.
Source: Folia Biologica
Authors: F. Sandor, Milan Buc
Institution: Comenius University Bratislava
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Award: G5713554480
OpenAlex ID: W158679766